In some ways this appears to be the most obvious part of design – after all if you already have a logo in the upper left, you're not going to place content on top of it. But you also need to think about the context of your positions. Placing an ad block in the middle of a text block implies a sense of connection between the two elements. Placing a horizontal line after a headline or by-line can create a sense of disconnect between the title or by-line and the content.
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